Clinical trials and evidence
Clinical trials and real-world evidence support evidence-based medicine in healthcare, playing a pivotal role in validating and advancing medical treatments and interventions. Clinical trials assess the efficacy and safety of new drugs and therapies, with real-world evidence providing data to inform clinical and regulatory decisions based on empirical data.
Top Stories
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13 Aug 2024
FDA approves first nasal spray for anaphylaxis
The FDA's approval of neffy offers a needle-free option for treating anaphylaxis, potentially improving patient access and compliance. Continue Reading
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30 Jul 2024
New mRNA vaccine initiative targets avian influenza (H5N1)
A new initiative led by WHO and MPP aims to develop mRNA vaccines for avian influenza (H5N1), boosting global pandemic preparedness. Continue Reading
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23 Jul 2024
Roche’s weight-loss drug trials yield positive results
Roche's $2.7B investment in Carmot's GLP-1 drugs shows promising early weight-loss results, positioning it as a strong market contender. Continue Reading
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22 Jul 2024
Effectively incorporating AI into drug research, development
A recent report from Accenture analyzes the value and impact AI can have on drug research and development. Continue Reading
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19 Jul 2024
Antimicrobial-resistant hospital-acquired infections increased 20%
New CDC data indicates that bacterial antimicrobial-resistant hospital-acquired infections increased by 20% during the pandemic. Continue Reading
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18 Jul 2024
CBD cream may protect against UVA-induced skin aging
A small study revealed that nano-encapsulated CBD cream may protect against aging, preventing UVA-induced nuclear and mitochondrial DNA damage. Continue Reading
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16 Jul 2024
Global pediatric immunization rates stall, threatening public health
The WHO revealed that childhood immunization rates stalled in 2023, leaving many infants in countries with low vaccine coverage. Continue Reading
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12 Jul 2024
Pfizer advances daily oral GLP-1 research
The company plans to launch dose optimization studies for a once-daily modified-release formulation for danuglipron. Continue Reading
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09 Jul 2024
GLP-1 drugs reduce the risk of obesity-associated cancers
Compared to insulin, GLP-1 drugs were better at preventing 10 of 13 obesity-associated cancers. Continue Reading
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24 Jun 2024
Understanding the endocannabinoid system's role in maintaining physiological balance
The endocannabinoid system, a complex cell-signaling network, is vital in maintaining physiological balance by regulating key processes such as mood, pain, and immune response. Continue Reading
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18 Jun 2024
Labcorp Global Trial Connect offers tools for clinical trials
The tool is marketed as a suite of central laboratory solutions for investigator sites, which should accelerate the speed of trials. Continue Reading
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07 Jun 2024
NIH launches two clinical trials on long-acting HIV PrEP
Gilead Sciences Inc. is funding two studies on long-acting human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) through the HIV Prevention Trials Network (HPTN). Continue Reading
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28 May 2024
Exploring 5 types of clinical trial data sharing platforms
Trial registries, result repositories, open data platforms, sponsor-specific platforms, and consortium-based platforms are five types of clinical trial data-sharing platforms. Continue Reading
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23 May 2024
Getting new antimicrobials to patients combatting drug resistance
A report from the Access to Medicines Foundation outlines strategies for getting new antimicrobial drugs to patients who need them. Continue Reading
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21 May 2024
FNIH launches public–private partnership to accelerate ALS research
The AMP ALS program is supported by multiple organizations, including the NINDS, FDA, the ALS association, Target ALS, and more. Continue Reading
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17 May 2024
US overdose deaths declined for the first time in 5 years
Despite ongoing challenges with the fentanyl supply, the CDC reports the first drop in US overdose deaths in five years. Continue Reading
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14 May 2024
Exploring FDA-approved GLP-1 receptor agonists
Glucagon-like peptide-1 (GLP-1) receptor agonists regulate blood sugar and aid weight loss, offering diverse applications beyond diabetes treatment. Continue Reading
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10 May 2024
NIH launches long COVID trials studying sleep, exercise, malaise
The clinical trials, part of the NIH RECOVER initiative, will explore sleep disturbances, exercise intolerance, and post-exertional malaise, testing four treatments. Continue Reading
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09 May 2024
Pfizer pauses phase 3 CIFFREO crossover trial for DMD
After a patient death in the phase 2 DAYLIGHT study, Pfizer has decided to pause the phase 3 CIFFREO crossover trial for DMD. Continue Reading
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06 May 2024
Addressing challenges in nucleotide therapeutic delivery
Walter Strapps, PhD, Chief Scientific Officer at Liberate Bio, discusses ongoing challenges with nucleotide therapeutic delivery and how Liberate is addressing them. Continue Reading
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03 May 2024
Dose-sparing mpox vaccine regimen is safe and effective
NIH-sponsored research revealed that a lower dose of the mpox vaccine was safe and produced a similar antibody response to the standard protocol. Continue Reading
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25 Apr 2024
Metformin use is associated with reduced cancer risk
A study from the National Cancer Institute found that metformin use was linked to lower cancer risk, primarily gastrointestinal, urologic, and hematologic cancer. Continue Reading
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12 Apr 2024
DMARDs for rheumatoid arthritis linked to lower dementia risk
A study evaluating the link between rheumatoid arthritis treatment and dementia risk linked the use of DMARDs to lower dementia rates. Continue Reading
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10 Apr 2024
Roughly 65% of bandages on the market contain forever chemicals
An analysis of 40 bandages by Mamavation revealed that most bandages on the market contain PFAS. Continue Reading
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02 Apr 2024
Addressing muscle loss associated with GLP-1 medication use
Scholar Rock is running a proof-of-concept study to mitigate muscle loss and enhance muscle mass in patients using GLP-1 drugs for weight management. Continue Reading
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01 Apr 2024
Tailoring medication selection with pharmacogenomic testing
Pharmacogenomic testing identifies genetic factors affecting drug response and reduces the risk of adverse reactions. Continue Reading
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26 Mar 2024
Comparing inflammatory bowel disease treatment options
Marla Dubinsky, MD, compares risankizumab and ustekinumab as second-line treatments for inflammatory bowel disease. Continue Reading
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25 Mar 2024
Understanding HIV drug resistance, implications for treatment strategies
Understanding HIV drug resistance aids in developing effective treatments, optimizing patient care, and combating therapeutic failure in HIV management. Continue Reading
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22 Mar 2024
Age-adjusted drug overdose deaths stabilized from 2021 to 2022
While drug overdose deaths declined in younger patients and increased in older individuals, the overall age-adjusted drug overdose deaths remained stable. Continue Reading
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13 Mar 2024
Acne treatments contain harmful levels of benzoyl peroxide
An independent lab analysis found that multiple products, including acne treatments, contain high levels of benzoyl peroxide, up to 800 times greater than the regulatory limit. Continue Reading
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08 Mar 2024
WHO reports increasing rates of HIV drug resistance to dolutegravir
A WHO press release highlighted trends from its 2024 HIV Drug Resistance Report, revealing increased resistance rates to dolutegravir. Continue Reading
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07 Mar 2024
Semaglutide Minimizes MASLD Severity in Patients with HIV
An NIH-funded study found a correlation between semaglutide use and reduced metabolic dysfunction-associated steatotic liver disease severity in HIV-positive patients. Continue Reading
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23 Feb 2024
NIH Launches Cancer Screening Research Network for Early Detection
The NIH has launched the Cancer Screening Research Network to evaluate cancer screening methods and technologies, supporting the White House’s Cancer Moonshot. Continue Reading
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22 Feb 2024
Injectable HIV ART Is an Effective Alternative to Oral Medications
An NIAID-sponsored study concluded that injectable HIV antiretroviral therapies are effective for patients who are not effectively treated with oral medications. Continue Reading
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21 Feb 2024
Almost Half of Infants in the US Have Received the RSV Vaccine
A CDC report noted that 40.5% of infants under eight months have received nirsevimab, the RSV vaccine, while 21.7% of parents plan to get their infants vaccinated. Continue Reading
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13 Feb 2024
What Is the Role of the Accelerating Medicines Partnership?
The accelerating medicines partnerships are multifaceted, including collaborative healthcare research efforts at the cross-section of academia, patient care, and industry. Continue Reading
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09 Feb 2024
10% of Premature Births Linked to Phthalate Exposure In Utero
A study in the Lancet Planetary Health linked maternal phthalate exposure to adverse birth outcomes, including 10% of premature births. Continue Reading
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08 Feb 2024
GLP-1 Medication Use Is Linked with Lower Anxiety, Depression Rates
Epic Research published a study revealing a correlation between some GLP-1 drugs and lower diagnostic rates of anxiety and depression. Continue Reading
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06 Feb 2024
GLP-1 Receptor Agonists Reduce 24-Hour Ambulatory Blood Pressure
Data from the SURMOUNT-1 study on tirzepatide revealed that it can reduce 24-hour ambulatory blood pressure. Continue Reading
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31 Jan 2024
Vertex Non-Opioid Drug Is an Effective Pain Management Medication
Vertex Pharmaceutical announced the positive results from a phase 3 clinical trial on VX-548, a non-opioid pain management drug, in a press announcement. Continue Reading
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26 Jan 2024
Patients Maintain Weight Loss One Year After Discontinuing GLP-1 Drugs
An Epic Research study evaluating the long-term effects of GLP-1 drugs noted that patients maintained weight loss for one year after stopping semaglutide and liraglutide. Continue Reading
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19 Jan 2024
NIH-Developed Antibodies Neutralize HIV in Animal Studies
A proof-of-concept animal study on rhesus macaques proved that an NIH-developed antibody can protect against various strains of HIV. Continue Reading
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18 Jan 2024
CVS Report Predicts 2024 Trends in Community Pharmacy
The Rx Report published by CVS Health evaluated multiple trends in community pharmacy and predicted their future changes. Continue Reading
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08 Jan 2024
Ethical Guidelines, Emerging Regulations in Octopus Research
Understanding octopus research guidelines is essential for ethical healthcare progress, ensuring breakthroughs align with moral standards and prioritize animal welfare. Continue Reading
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04 Jan 2024
Semaglutide Reduces Weight in Patients with Failed Bariatric Surgery
A study published in Obesity revealed that weekly semaglutide injections helped manage weight in severely obese patients who had unsuccessful results with bariatric surgery. Continue Reading
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21 Dec 2023
Psilocybin-Assisted Group Therapy Manages MDD in Cancer Patients
A phase 2 open-label clinical trial on cancer patients with MDD determined that psilocybin-assisted group therapy is a safe, feasible, and effective treatment. Continue Reading
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27 Nov 2023
Ensuring Equal Clinical Trial Access Across Vulnerable Communities
CVS Health focuses on clinical trial diversity and inclusion by engaging vulnerable communities. Continue Reading
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16 Nov 2023
How to Effectively Integrate AI into Clinical Trials
PharmaNewsIntelligence interviews Tobias Guennel on effective AI integration, safety, and validation in clinical trials. Continue Reading
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03 Nov 2023
Researchers Reveal Positive Data on New Antibiotic for Super Gonorrhea
A phase 3 clinical trial revealed that a new antibiotic, the first in its class, may treat antibiotic-resistant super gonorrhea. Continue Reading
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28 Sep 2023
Only 46% of US Adults Are Planning to Get the COVID-19 Vaccine Booster
Based on estimates from a KFF survey, 23% of adults reported they would definitely get the vaccine, while an additional 23% said they would probably get it. Continue Reading
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26 Sep 2023
Revolutionizing Clinical Trial Data Tracking, Analysis with Technology
Healthcare technology is revolutionizing the tracking and analysis of clinical trial data, boosting efficiency, accuracy, and the discovery of breakthrough treatments. Continue Reading
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22 Sep 2023
Semaglutide Treatment Reduces Heart Failure Symptoms in Obese Patients
Obese heart failure patients with preserved ejection fractions have reduced symptoms when treated with 2.4 mg of semaglutide. Continue Reading
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21 Sep 2023
HIV Vaccine Clinical Trials Begin in the US and South Africa
Funded, in part, by the NIAID, the vaccine trials will enroll 95 HIV-negative participants with asymptomatic CMV. Continue Reading
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18 Aug 2023
Taking Anti-Inflammatory Medication with Plan B Improves Effectiveness
A recent Lancet study revealed that piroxicam improves the effectiveness of levonorgestrel within three days of unprotected sex. Continue Reading
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16 Aug 2023
Understanding HIV Drug Resistance, Minimizing Disease Transmission
Minimizing HIV transmission requires a multifaceted approach, including understanding HIV drug resistance and its implications. Continue Reading
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14 Aug 2023
Vaccinations Needed to Prevent COVID-19 ED Visits, Hospitalization
Researchers quantified the number needed to vaccinate to eliminate one COVID-19 ED visit or hospitalization. Continue Reading
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27 Jul 2023
Zuranolone Effectively and Safely Treats Postpartum Depression
Zuranolone treats postpartum depression without loss of consciousness, withdrawal symptoms, or increased suicidal ideation. Continue Reading
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26 Jul 2023
Only 3.3% of NIH-Funded Pediatric Clinical Trials Data Is Reusable
Across NIH-funded pediatric clinical trials, only 3.3% provide accessible and reusable individual participant data. Continue Reading
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24 Jul 2023
Applications of Psilocybin in Mental Health Disorder Treatments
A recent revolution in psychedelics has caused researchers to explore the applications of psilocybin in mental health disorder treatments. Continue Reading
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19 Jul 2023
Top 3 Use Cases for Psychedelics, Understanding Ongoing Research
Ongoing clinical research in psychedelics primarily focuses on 3 prominent use cases: anxiety and depression, PTSD, and substance use disorders. Continue Reading
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17 Jul 2023
Melanoma Drugs Repurposed Can Shrink Rare Brain Tumors
BRAF–MEK inhibitors, melanoma drugs, can be repurposed to treat papillary craniopharyngiomas, a rare brain tumor. Continue Reading
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13 Jul 2023
Majority of Patients Quit Weight-Loss Drugs Like Wegovy Within First Year
Reuters exclusive reporting found that two-thirds of patients discontinue using weight-loss drugs before achieving lasting health improvements. Continue Reading
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13 Jul 2023
How Monoclonal Antibodies Are Shaping the Future of Healthcare
Monoclonal antibodies have unleashed the power of precision medicine for various medical conditions. Continue Reading
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10 Jul 2023
45% of Drinking Water Samples in the United States Contain PFAS
Drinking water in the US may contain one to nine PFAS chemicals that can have long-term, significant health implications. Continue Reading
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29 Jun 2023
GSK Receives Fast Track from FDA for Gonorrhea Vaccine
The vaccine is part of GSK’s quest to combat antimicrobial resistance across several domains. Continue Reading
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28 Jun 2023
Retatrutide Helps Patients Achieve 17.5% Weight Reduction at 24 Weeks
Reteratrutide, Eli Lilly’s newest experimental weight loss drug, helps patients achieve a 17.5% weight reduction at 24 weeks in a phase 2 clinical trial. Continue Reading
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26 Jun 2023
FDA Launches Programs to Reduce Risk of Cancer Biomarker Testing
The FDA launched a pilot program aimed at sponsors of oncology drugs to reduce the risk of cancer biomarker testing. Continue Reading
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19 Jun 2023
Men in the US Are More Likely to Have a Fatal Overdose Than Women
NIH study finds US men 2–3 times more likely to have fatal overdose than women during 2020–2021. Continue Reading
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13 Jun 2023
Government Health Leaders Request Additional Data on Drug Test Strips
Commentary in the New England Journal of Medicine from government health leaders at the NIH and FDA request additional data and research on fentanyl drug test strips. Continue Reading
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08 Jun 2023
Merck and Moderna Skin Cancer Vaccine Significantly Reduces Risk of Death
The experimental vaccine is just the beginning of mRNA cancer treatments. Continue Reading
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06 Jun 2023
National Cancer Institute Launches Precision Medicine Initiative
The National Cancer Institute has launched a new precision medicine initiative called ComboMATCH to test drug combinations based on tumor biology. Continue Reading
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05 Jun 2023
Adverse Birth Outcome Linked to Forever Chemical Exposure in Pregnancy
A cohort study published in JAMA Network Open has linked early pregnancy exposure to forever chemicals, PFAS, to adverse birth outcomes in mothers with low folate. Continue Reading
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31 May 2023
Ketamine and ECT Equally Effective for Treatment-Resistant Depression
A recent study published in the New England Journal of Medicine revealed that ketamine therapy and ECT are equally effective for nonpsychotic treatment-resistant depression. Continue Reading
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30 May 2023
High Prescription Drug Costs Lead Older Patients to Ration Medication
A study published in JAMA Network Open found that high prescription drug costs have caused older patients over 65 to ration medications, limiting treatment adherence. Continue Reading
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26 May 2023
Researchers Explore Ozempic as a Potential Addiction Treatment
Following patient testimony on its ability to curb addiction, researchers have begun preclinical studies exploring Ozempic as a potential addiction treatment. Continue Reading
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25 May 2023
Addressing Clinical Trial Challenges and High Drug Development Costs
Clinical researchers seek new tools and assets to address clinical trial challenges linked to high drug development costs. Continue Reading
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24 May 2023
FDA Approves New Opioid Reversal Nasal Spray, A Harm Reduction Tool
The FDA added a new harm-reduction tool to the arsenal against opioid overdose by approving a new opioid reversal nasal spray similar to naloxone. Continue Reading
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23 May 2023
FDA Approves Abbvie’s Medication for Crohn’s Disease in Adults
The US FDA has provided an alternative treatment for adults with moderate or severely active Crohn’s disease by approving Abbvie’s RINVOQ as a once-daily pill. Continue Reading
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23 May 2023
FNIH Enhances Rare Disease Research by Adding 8 Diseases to BGTC
A recent announcement by the FNIH revealed it would add eight rare diseases to its BGTC to accelerate and enhance rare disease research, providing a template for future efforts. Continue Reading
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19 May 2023
Promising Results Seen in Pancreatic Cancer mRNA Vaccine Trials
A recent Memorial Sloan Kettering Cancer Center announcement revealed promising results from a phase 1 clinical trial to treat pancreatic cancer with mRNA vaccines. Continue Reading
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18 May 2023
NIH Researchers Begin Clinical Trials on a Universal Influenza Vaccine
NIH researchers have begun recruiting healthy volunteers for a phase 1 clinical trial, studying a universal mRNA influenza vaccine. Continue Reading
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16 May 2023
Exploring FDA-Approved Drugs and Potential Treatment Options for ALS
Researchers are actively exploring a range of FDA-approved drugs and potential treatment options for amyotrophic lateral sclerosis. Continue Reading
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11 May 2023
Department of Agriculture Licenses Lyme Vaccine for Use in Wild Mice
Officials hope the vaccine will reduce the spread of Lyme in the environment and decrease the disease burden in humans. Continue Reading
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08 May 2023
Sleeping Pills Linked to Lower Levels of Alzheimer's Disease Proteins
A small clinical trial linked suvorexant, a type of sleeping pill, to lower levels of Alzheimer’s disease proteins, such as tau and amyloid proteins. Continue Reading
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08 May 2023
Oral Ketamine Treatment: An Alternative to Ketamine Infusions
Despite proven efficacy in managing treatment-resistant depression, ketamine therapy can have multiple limitations; however, oral ketamine treatment may provide a more accessible alternative. Continue Reading
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05 May 2023
A Melatonin Study Highlights a Lack of Supplement Regulation
A recent study on melatonin, analyzing the levels in 30 melatonin gummies, highlighted a lack of supplement regulation and oversight. Continue Reading
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02 May 2023
Advancing Health Equity with Clinical Trial Diversity: Key Strategies
Although research has consistently displayed a lack of participant diversity in clinical trials, improving clinical trial diversity is a key strategy for advancing health equity. Continue Reading
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01 May 2023
Research Reveals That Forever Chemicals May Be Linked to Weight Gain
Research published in Obesity revealed that forever chemicals might be linked to another human health issue: weight gain. Continue Reading
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28 Apr 2023
Nearly 1 Million Deaths Annually Are Linked to Antimicrobial Resistance
A report published by the World Animal Protection nonprofit estimated that nearly one million deaths worldwide are linked to antimicrobial resistance annually. Continue Reading
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25 Apr 2023
Neutralizing Monoclonal Antibodies for COVID-19 Reduces ED Visits
A cohort study published in JAMA Network Open analyzed the impact of neutralizing monoclonal antibodies in COVID patients, finding reduced ED visits, hospitalizations, and deaths. Continue Reading
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21 Apr 2023
Study Links Stimulant Prescription Rates to Teen Drug Misuse
A study analyzing stimulant prescription rates among students in secondary schools linked high prescription rates to higher rates of teen drug misuse or nonmedical use. Continue Reading
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17 Apr 2023
Vertex and CRISPR Submit BLA for Sickle Cell Disease Treatment
Vertex Pharmaceuticals and CRISPR Therapeutics have submitted Biological License Applications to the FDA for sickle cell disease and transfusion-dependent beta-thalassemia treatments. Continue Reading
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13 Apr 2023
A New Era in Medicine: The Therapeutic Promise of HMO-Based Medications
Human milk oligosaccharides (HMOs) are complex carbohydrates in human breast milk that have numerous health benefits, spurring research efforts to develop a promising new class of drugs. Continue Reading
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12 Apr 2023
NIH Study Finds That Post-Exposure Doxycycline Reduces STI Rate
A recent NIH funded study found that post-exposure oral doxycycline reduces STI rates, including chlamydia, gonorrhea, and syphilis, by two-thirds. Continue Reading
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27 Mar 2023
Nectin Therapeutics Collaborates with Merck on Cancer Treatment
Nectin Therapeutics and Merck have collaborated on a new cancer treatment that combines Keytruda with a novel anti-PVR antibody treatment. Continue Reading
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24 Mar 2023
Phase 1 Clinical Trial Achieves Leukemia Remission in 18 Patients
Of the 68 patients enrolled in a phase 1 clinical trial testing revumenib, 18 achieved complete or nearly complete remission. Continue Reading
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06 Mar 2023
Less Than 55% of Pediatric Clinical Trial Results Are Published
A research letter analyzing the distribution of information from pediatric clinical trials determined that less than 55% of pediatric trials are published within four years of trial completion. Continue Reading
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27 Feb 2023
The Importance of Delaying the Onset of Type 1 Diabetes with New Treatment
For those with type 1 diabetes, a new monoclonal antibody treatment delays the clinical diagnosis of stage 3 diabetes for 2 years, pausing disease burdens and improving the quality of life. Continue Reading
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23 Feb 2023
Pfizer Eyeing Expedited FDA Approval for RSV Vaccine
The single-dose mRNA vaccine administered to expectant mothers could be ready for a fall surge of RSV in the United States. Continue Reading
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15 Feb 2023
Developing Clinical Trial Budgets, Considerations, and Best Practices
Although there are some best practices for developing clinical trial budgets, the many considerations and factors required to create a budget can complicate it. Continue Reading
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15 Feb 2023
CDC Analyzes Sleep Medication Usage by Adults in the United States
In a study by the National Center for Health Statistics, the CDC analyzes sleep medication use by adults in the US, noting that 18.4% have used sleep medication in the past 30 days. Continue Reading
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13 Feb 2023
Effectively Managing Clinical Trials, Recruitment, and Adaptive Trials
Learning how to effectively manage clinical trials, from recruitment to trial design and adaptability, is critical for the economic well-being of clinical research organizations. Continue Reading