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Thermo Fisher Introduces System to Enable Cell Therapy Development
Providers can leverage the system to overcome manufacturing challenges that hinder cell therapy production, bringing life-saving therapies to patients faster.
Thermo Fisher Scientific recently introduced a new large-volume electroporation system that allows cell therapy developers to quickly move from clinical development to commercial manufacturing.
The Gibco CTS Xenon Electroporation System leverages a closed, highly flexible design to facilitate gene modifications without traditional viral vectors. The electroporation approach allows a payload into a cell by temporarily boosting cell permeability using an electrical pulse.
Additionally, the system features programmable, flexible electroporation conditions, giving cell therapy developers complete control to optimize various hard-to-transfect cell types and payloads, a Thermo Fisher spokesperson explained.
Providers can use the technology as a standalone tool or integrated with the Gibco CTS Rotea Counterflow Centrifugation System as part of a modular, automated cell therapy manufacturing workflow.
“We launched the CTS Rotea System in 2020 as part of our strategy to deliver fit-for-purpose cell therapy solutions that can easily scale from development to commercialization,” Amy Butler, president of biosciences at Thermo Fisher, said in the announcement.
“Adding the CTS Xenon Electroporation System to our end-to-end workflow will help customers overcome manufacturing challenges that hinder production, enabling them to bring life-saving therapies to patients faster,” Butler continued.
Notably, the CTS Xenon Electroporation System can transfect up to 2.5e9 cells in 25 milliliters in a sterile system, enabling rapid and efficient non-viral transfection for clinical manufacturing applications.
The system also delivers up to 80% cell viability and 90% gene knockout transfection to seamlessly scale from the small-volume Neon Transfection System without re-optimizing electroporation parameters.
Thermo Fisher’s CTS product line offers a detailed portfolio of GMP-manufactured products that work synergistically across the entire workflow, from cell isolation and activation to cell engineering and expansion, to address cell therapy developers’ manufacturing needs.
